Effect of colchicine on the antibody response. I. Enhancement of antibody formation in mice.

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Effect of colchicine on the antibody response. I. Enhancement of antibody formation in mice

Colchicine (CC) enhances the antibody response in mice to protein antigens, like diphtheria toxoid and human gamma globulin, as well as to the 2,4,6-trinitrophenyl hapten. Maximal enhancement was observed when CC was administered to animals on the same day as the injection of antigen. The optimal dose of CC was in the range of 1.0-1.5 mg/kg body weight. The enhanced antibody formation was evide...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1978

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.147.4.1213